Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression

Failure to cure ovarian cancer relates to the persistence of dormant, drug-resistant cancer cells following surgery and chemotherapy. “Second look” surgery can detect small, poorly vascularized nodules of persistent ovarian cancer in ~50% of patients, where >80% are underg...

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Bibliographic Details
Main Authors: Margie N. Sutton, Gilbert Y. Huang, Jinhua Zhou, Weiqun Mao, Robert Langley, Zhen Lu, Robert C. Bast
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/11/5/603