Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors

Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors

Serotonin receptors play important roles in neuronal excitation, emotion, platelet aggregation, and vasoconstriction. The serotonin receptor subtype 2A (5-HT<sub>2A</sub>R) is a Gq-coupled GPCR, which activate phospholipase C. Although the structures and functions of 5-HT<sub>2A<...

Full description

Bibliographic Details
Main Authors: Kazuhiro Mio, Shoko Fujimura, Masaki Ishihara, Masahiro Kuramochi, Hiroshi Sekiguchi, Tai Kubo, Yuji C. Sasaki
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
GPCR
5-HT<sub>2A</sub> receptor
intramolecular dynamics
live cell
X-ray diffraction analysis
Online Access:https://www.mdpi.com/1422-0067/22/10/5285

Internet

https://www.mdpi.com/1422-0067/22/10/5285

Similar Items