DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory

DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory

DPP6 is well known as an auxiliary subunit of Kv4-containing, A-type K+ channels which regulate dendritic excitability in hippocampal CA1 pyramidal neurons. We have recently reported, however, a novel role for DPP6 in regulating dendritic filopodia formation and stability, affecting synaptic develop...

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Bibliographic Details
Main Authors: Lin Lin, Jonathan G. Murphy, Rose-Marie Karlsson, Ronald S. Petralia, Jakob J. Gutzmann, Daniel Abebe, Ya-Xian Wang, Heather A. Cameron, Dax A. Hoffman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
DPP6
neurodevelopment
learning and memory
autism spectrum disorder
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00084/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00084/full

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