A cell culture model for monitoring α-synuclein cell-to-cell transfer

The transfer of α-synuclein (α-syn) between cells has been proposed to be the primary mechanism of disease spreading in Parkinson's disease. Several cellular models exist that monitor the uptake of recombinant α-syn from the culture medium. Here we established a more physiologically relevant mo...

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Bibliographic Details
Main Authors: Juan F. Reyes, Tomas T. Olsson, Jennifer T. Lamberts, Michael J. Devine, Tilo Kunath, Patrik Brundin
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Neurobiology of Disease
Subjects:
HCA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001971