In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition

In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition

Abstract Pathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease (PD). Intracellular pathological inclusions of the protein α-synuclein within dopaminergic neurons are a cardinal feature of PD, but the mechanisms by which α-synucl...

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Bibliographic Details
Main Authors: Min Lin, Phillip M. Mackie, Fatima Shaerzadeh, Joyonna Gamble-George, Douglas R. Miller, Chris J. Martyniuk, Habibeh Khoshbouei
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Acta Neuropathologica Communications
Subjects:
α-synuclein
iPSCs
Dopamine neurons
D2 receptor
Parkinson’s disease
Online Access:https://doi.org/10.1186/s40478-021-01203-9

Internet

https://doi.org/10.1186/s40478-021-01203-9

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