Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-...

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Main Authors: Kimberley J Evason, Macrina T Francisco, Vladislava Juric, Sanjeev Balakrishnan, Maria Del Pilar Lopez Pazmino, John D Gordan, Sanjay Kakar, Jan Spitsbergen, Andrei Goga, Didier Y R Stainier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4489858?pdf=render

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http://europepmc.org/articles/PMC4489858?pdf=render

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