K6PC-5 Activates SphK1-Nrf2 Signaling to Protect Neuronal Cells from Oxygen Glucose Deprivation/Re-Oxygenation

K6PC-5 Activates SphK1-Nrf2 Signaling to Protect Neuronal Cells from Oxygen Glucose Deprivation/Re-Oxygenation

Background/Aims: New strategies are required to combat neuronal ischemia-reperfusion injuries. K6PC-5 is a novel sphingosine kinase 1 (SphK1) activator whose potential activity in neuronal cells has not yet been tested. Methods: Cell survival and necrosis were assessed with a Cell Counting Kit-8 ass...

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Bibliographic Details
Main Authors: Hua Liu, Zhiqing Zhang, Min Xu, Rong Xu, Zhichun Wang, Guangfu Di
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Neuron
K6PC-5
SphK1
Nrf2
Oxidative stress
Online Access:https://www.karger.com/Article/FullText/495716

Internet

https://www.karger.com/Article/FullText/495716

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