Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice

Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice

Abstract Zika virus (ZIKV), a flavivirus transmitted primarily by infected mosquitos, can cause neurological symptoms such as Guillian–Barré syndrome and microcephaly. We developed several vaccinia virus (VACV) vaccine candidates for ZIKV based on replication-inducible VACVs (vINDs) expressing ZIKV...

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Bibliographic Details
Main Authors: Brittany Jasperse, Caitlin M. O’Connell, Yuxiang Wang, Paulo H. Verardi
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85951-7

Internet

https://doi.org/10.1038/s41598-021-85951-7

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