Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1.

Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1.

Functional differences between healthy progenitor and cancer initiating cells may provide unique opportunities for targeted therapy approaches. Hematopoietic stem cells are tightly controlled by a network of CDK inhibitors that govern proliferation and prevent stem cell exhaustion. Loss of Inca1 led...

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Bibliographic Details
Main Authors: Nicole Bäumer, Sebastian Bäumer, Frank Berkenfeld, Martin Stehling, Gabriele Köhler, Wolfgang E Berdel, Carsten Müller-Tidow, Petra Tschanter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4272264?pdf=render

Internet

http://europepmc.org/articles/PMC4272264?pdf=render

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