Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria

Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria

It is well established that CNS axons fail to regenerate, undergo retrograde dieback, and form dystrophic growth cones due to both intrinsic and extrinsic factors. We sought to investigate the role of axonal mitochondria in the axonal response to injury. A viral vector (AAV) containing a mitochondri...

Full description

Bibliographic Details
Main Authors: Joseph Kedra, Shen Lin, Almudena Pacheco, Gianluca Gallo, George M. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
regeneration
mitochondria
mitophagy
corticospinal tract (CST)
spinal cord injury
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.668670/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.668670/full

Similar Items