Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway

Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway

Sarcopenia is an aging-induced syndrome characterized by a progressive reduction of skeletal muscle mass and strength. Increasing evidence has attested that appropriate and scientific exercise could induce autophagy or optimize the functional status of autophagy, which plays a critical role in senes...

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Bibliographic Details
Main Authors: Jiling Liang, Hu Zhang, Zhengzhong Zeng, Liangwen Wu, Ying Zhang, Yanju Guo, Jun Lv, Cenyi Wang, Jingjing Fan, Ning Chen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Metabolites
Subjects:
lifelong aerobic exercise
sarcopenia
autophagy
apoptosis
mitochondrial quality control
ubiquitin-proteasome system
Online Access:https://www.mdpi.com/2218-1989/11/5/323

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https://www.mdpi.com/2218-1989/11/5/323

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