The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis.

The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis.

Streptococcus agalactiae (Group B Streptococcus, GBS) normally colonizes healthy adults but can cause invasive disease, such as meningitis, in the newborn. To gain access to the central nervous system, GBS must interact with and penetrate brain or meningeal blood vessels; however, the exact mechanis...

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Bibliographic Details
Main Authors: Liwen Deng, Brady L Spencer, Joshua A Holmes, Rong Mu, Sara Rego, Thomas A Weston, Yoonsung Hu, Glenda F Sanches, Sunghyun Yoon, Nogi Park, Prescilla E Nagao, Howard F Jenkinson, Justin A Thornton, Keun Seok Seo, Angela H Nobbs, Kelly S Doran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007848

Internet

https://doi.org/10.1371/journal.ppat.1007848

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