Resolving Early Signaling Events in T-Cell Activation Leading to IL-2 and FOXP3 Transcription

Resolving Early Signaling Events in T-Cell Activation Leading to IL-2 and FOXP3 Transcription

Signal intensity and feedback regulation are known to be major factors in the signaling events stemming from the T-cell receptor (TCR) and its various coreceptors, but the exact nature of these relationships remains in question. We present a mathematical model of the complex signaling network involv...

Full description

Bibliographic Details
Main Authors: Jeffrey P. Perley, Judith Mikolajczak, Gregery T. Buzzard, Marietta L. Harrison, Ann E. Rundell
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Processes
Subjects:
T-cell activation
CD28 costimulation
calcium
Erk
NFkB
mTOR
CD45
SHP1
mathematical model
Online Access:http://www.mdpi.com/2227-9717/2/4/867

Internet

http://www.mdpi.com/2227-9717/2/4/867

Similar Items