Somatic populations of PGT135-137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatics

Somatic populations of PGT135-137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatics

Select HIV-1-infected individuals develop sera capable of neutralizing diverse viral strains. The molecular basis of this neutralization is currently being deciphered by the isolation of HIV-1-neutralizing antibodies. In one infected donor, three neutralizing antibodies, PGT135-137, were identified...

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Bibliographic Details
Main Authors: Jiang eZhu, Sijy eO’Dell, Gilad eOfek, Marie ePancera, Xueling eWu, Baoshan eZhang, Zhenhai eZhang, NISC eComparative Sequencing Program, James C. Mullikin, Melissa eSimek, Dennis R. Burton, Wayne C. Koff, Lawrence eShapiro, John R. Mascola, Peter D Kwong
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
Immunity
Deep sequencing
Antibody bioinformatics
N-linked glycan
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00315/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00315/full

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