Regulation of B cell fate by chronic activity of the IgE B cell receptor

Regulation of B cell fate by chronic activity of the IgE B cell receptor

IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, the IgE BCR promoted terminal differentiation of B...

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Bibliographic Details
Main Authors: Zhiyong Yang, Marcus J Robinson, Xiangjun Chen, Geoffrey A Smith, Jack Taunton, Wanli Liu, Christopher D C Allen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
B cell receptor
signaling
germinal center
plasma cell
antigen presentation
T cell help
Online Access:https://elifesciences.org/articles/21238

Internet

https://elifesciences.org/articles/21238

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