Candidacidal Activity of a Novel Killer Toxin from Wickerhamomyces anomalus against Fluconazole-Susceptible and -Resistant Strains

Candidacidal Activity of a Novel Killer Toxin from Wickerhamomyces anomalus against Fluconazole-Susceptible and -Resistant Strains

The isolation and characterization from the sand fly Phlebotomus perniciosus of a Wickerhamomyces anomalus yeast strain (Wa1F1) displaying the killer phenotype was recently reported. In the present work, the killer toxin (KT) produced by Wa1F1 was purified and characterized, and its antimicrobial ac...

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Bibliographic Details
Main Authors: Laura Giovati, Claudia Santinoli, Elena Ferrari, Tecla Ciociola, Elena Martin, Claudio Bandi, Irene Ricci, Sara Epis, Stefania Conti
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Toxins
Subjects:
Wickerhamomyces anomalus
yeast killer toxin
Candida albicans
Candida glabrata
antifungal resistance
Key Contribution
A novel killer toxin produced by the recently isolated Wickerhamomyces anomalus strain 1F1 showed a differential killing ability against fluconazole-susceptible and -resistant Candida clinical isolates and laboratory strains displaying known mutations.
Online Access:http://www.mdpi.com/2072-6651/10/2/68

Internet

http://www.mdpi.com/2072-6651/10/2/68

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