Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk Reduction

Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk Reduction

For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce the risk of miscarriage and genetic disease in patients with advanced maternal age and risk of transmitting disease. Recently developed methods of genome-wide genotyping and machine learning algorithms now of...

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Bibliographic Details
Main Authors: Nathan R. Treff, Jennifer Eccles, Lou Lello, Elan Bechor, Jeffrey Hsu, Kathryn Plunkett, Raymond Zimmerman, Bhavini Rana, Artem Samoilenko, Steven Hsu, Laurent C. A. M. Tellier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Endocrinology
Subjects:
polygenic risk score
preimplantation genetic testing
advanced maternal age
aneuploidy
type 1 diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00845/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00845/full

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