Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia

Abstract The N-methyl-d-aspartate receptor hypofunction is one of the most prevalent models of schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d-aspartate receptor antagonists elicit positive, negative, and cognitive-like symptoms of schizophrenia. Patients with anti...

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Bibliographic Details
Main Authors: Kazu Nakazawa, Vivek Jeevakumar, Kazuhito Nakao
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:npj Schizophrenia
Online Access:https://doi.org/10.1038/s41537-016-0003-3