The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation

The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation

Abstract Background Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-L1) has been documented in several cancers and contributes to the evasion of the host immune system. However, cancer cell-intrinsic signaling-dependent control of PD-L1 expression remains to be elucidated. He...

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Bibliographic Details
Main Authors: Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang, Xiaomin Bian, Tingting Gu, Lianji Wen
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cell Communication and Signaling
Subjects:
Head and neck squamous cell carcinoma
Let-7 family
Programmed death-ligand 1
Immune evasion
Glycosylation
TCF-4
Online Access:https://doi.org/10.1186/s12964-019-0490-8

Internet

https://doi.org/10.1186/s12964-019-0490-8

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