Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Since its discovery in mice and humans 19 years ago, the contribution of alternatively spliced Stat3, Stat3β, to the overall functions of Stat3 has been controversial. Tyrosine-phosphorylated (p) Stat3β homodimers are more stable, bind DNA more avidly, are less susceptible to dephosphorylation, and...

Full description

Bibliographic Details
Main Authors: Uddalak Bharadwaj, Moses M. Kasembeli, T. Kris Eckols, Mikhail Kolosov, Paul Lang, Kurt Christensen, Dean P. Edwards, David J. Tweardy
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Cancers
Subjects:
Stat3β
Stat3 beta
isoform
alternative RNA splicing
CT7
phosphorylation
monoclonal
oncogenesis
breast cancer
regulation
Online Access:http://www.mdpi.com/2072-6694/6/4/2012

Internet

http://www.mdpi.com/2072-6694/6/4/2012

Similar Items