Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

Abstract Background Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to investigate the molecular mechanisms involved in Sirt6 protection agains...

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Bibliographic Details
Main Authors: Jiye Li, Dongsheng Yu, Sanyang Chen, Yifan Liu, Jihua Shi, Jiakai Zhang, Peihao Wen, Zhihui Wang, Jie Li, Wenzhi Guo, Shuijun Zhang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell & Bioscience
Subjects:
Sirt6
HiBEC
Cholestasis
PGC-1α
AMPK
Online Access:http://link.springer.com/article/10.1186/s13578-020-00402-6

Internet

http://link.springer.com/article/10.1186/s13578-020-00402-6

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