The Marine Fungal Metabolite, Dicitrinone B, Induces A375 Cell Apoptosis through the ROS-Related Caspase Pathway

The Marine Fungal Metabolite, Dicitrinone B, Induces A375 Cell Apoptosis through the ROS-Related Caspase Pathway

Dicitrinone B, a rare carbon-bridged citrinin dimer, was isolated from the marine-derived fungus, Penicillium citrinum. It was reported to have antitumor effects on tumor cells previously; however, the details of the mechanism remain unclear. In this study, we found that dicitrinone B inhibited the...

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Bibliographic Details
Main Authors: Li Chen, Mei-Wei Gong, Zhen-Fei Peng, Tong Zhou, Min-Gang Ying, Qiu-Hong Zheng, Qin-Ying Liu, Qi-Qing Zhang
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Marine Drugs
Subjects:
dicitrinone B
marine-derived fungus
human malignant melanoma cell A375
anticancer activity
apoptosis
Online Access:http://www.mdpi.com/1660-3397/12/4/1939

Internet

http://www.mdpi.com/1660-3397/12/4/1939

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