Synthesis and biological evaluation of the progenitor of a new class of cephalosporin analogues, with a particular focus on structure-based computational analysis.

Synthesis and biological evaluation of the progenitor of a new class of cephalosporin analogues, with a particular focus on structure-based computational analysis.

We present the synthesis and biological evaluation of the prototype of a new class of cephalosporins, containing an additional isolated beta lactam ring with two phenyl substituents. This new compound is effective against Gram positive microorganisms, with a potency similar to that of ceftriaxone, a...

Full description

Bibliographic Details
Main Authors: Anna Verdino, Giovanni Vigliotta, Deborah Giordano, Ivana Caputo, Annunziata Soriente, Margherita De Rosa, Anna Marabotti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5531512?pdf=render

Internet

http://europepmc.org/articles/PMC5531512?pdf=render

Similar Items