Changes in hippocampal GABAA/cBZR density during limbic epileptogenesis: Relationship to cell loss and mossy fibre sprouting

Changes in hippocampal GABAA/cBZR density during limbic epileptogenesis: Relationship to cell loss and mossy fibre sprouting

Reduced GABAA/central benzodiazepine receptor (GABAA/cBZR) density, mossy fibre sprouting (MFS) and hippocampal cell loss are well described pathological features of human temporal lobe epilepsy (TLE), and animal models thereof. However, the temporal relationship of their development, and their role...

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Bibliographic Details
Main Authors: L. Vivash, A. Tostevin, D.S.H. Liu, L. Dalic, S. Dedeurwaerdere, R.J Hicks, D.A. Williams, D.E. Myers, T.J. O'Brien
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Epileptogenesis
Temporal lobe epilepsy
γ-amino butyric acid type A/central benzodiazepine receptor
Hippocampus
Receptor density
Epilepsy seizures
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002937

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http://www.sciencedirect.com/science/article/pii/S0969996110002937

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