Chylomicronemia from GPIHBP1 autoantibodies

Chylomicronemia from GPIHBP1 autoantibodies

Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and transport of LPL by GPIHBP1, thereby disrupting t...

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Bibliographic Details
Main Authors: Kazuya Miyashita, Jens Lutz, Lisa C. Hudgins, Dana Toib, Ambika P. Ashraf, Wenxin Song, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Lipid Research
Subjects:
glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1
lipoprotein lipase
triglycerides
autoimmune disease
immunoglobulin A
immunoglobulin G4
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520437253

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http://www.sciencedirect.com/science/article/pii/S0022227520437253

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