Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model

Abnormally low level of interstitial oxygen, or hypoxia, is a hallmark of tumor microenvironment and a known promoter of cancer chemoresistance. Inside a solid tumor mass, the hypoxia stems largely from inadequate supply of oxygenated blood through sparse or misshapen tumor vasculature whilst oxygen...

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Bibliographic Details
Main Authors: Mateusz Rytelewski, Karine Harutyunyan, Natalia Baran, Saradhi Mallampati, M. Anna Zal, Antonio Cavazos, Jason M. Butler, Sergej Konoplev, Mirna El Khatib, Shane Plunkett, Joseph R. Marszalek, Michael Andreeff, Tomasz Zal, Marina Konopleva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00991/full