Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.

Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.

Berberine and its derivatives display potent analgesic, anti-inflammatory and anticancer activity. Here we aimed at characterizing the mechanism of action of berberine in the gastrointestinal (GI) tract and cortical neurons using animal models and in vitro tests.The effect of berberine was character...

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Bibliographic Details
Main Authors: Chunqiu Chen, Meiling Lu, Qiuhui Pan, Jakub Fichna, Lijun Zheng, Kesheng Wang, Zhen Yu, Yongyu Li, Kun Li, Aihong Song, Zhongchen Liu, Zhenshun Song, Martin Kreis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4689480?pdf=render

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http://europepmc.org/articles/PMC4689480?pdf=render

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