MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells

MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells

Abstract Background Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-to-hematopoietic transition (EHT) serves as the pivotal mechanism for t...

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Bibliographic Details
Main Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi, Jiaxi Zhou
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Stem Cell Research & Therapy
Subjects:
MSX2
TGF-β signaling
Endothelial to hematopoietic transition
Human embryonic stem cells
Hematopoietic differentiation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01653-3

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http://link.springer.com/article/10.1186/s13287-020-01653-3

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