Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs) were recently identified: mesenchymal (MES) and proneural (PN). To identify mechanisms to target the more aggressive MES GSCs, we combined transcripto...

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Bibliographic Details
Main Authors: Peng Cheng, Emma Phillips, Sung-Hak Kim, David Taylor, Thomas Hielscher, Laura Puccio, Anita B. Hjelmeland, Peter Lichter, Ichiro Nakano, Violaine Goidts
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000995

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http://www.sciencedirect.com/science/article/pii/S2213671115000995

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