Experimental and computational studies on a protonated 2-pyridinyl moiety and its switchable effect for the design of thermolytic devices.

1D and 2D NMR investigations as well as computational studies, including static quantum-mechanics calculations, density function theory formalism, and classical molecular dynamics, were applied to determine the protonation sites in the thermolabile protecting group (TPG) containing a 2-pyridynyl moi...

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Bibliographic Details
Main Authors: Jolanta Brzezinska, Jacek Kujawski, Agnieszka Witkowska, Kornelia Czaja, Marek K Bernard, Marcin K Chmielewski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6147472?pdf=render