HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality

HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality

Abstract Background Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune...

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Bibliographic Details
Main Authors: David M. Richards, Viola Marschall, Katharina Billian-Frey, Karl Heinonen, Christian Merz, Mauricio Redondo Müller, Julian P. Sefrin, Matthias Schröder, Jaromir Sykora, Harald Fricke, Oliver Hill, Christian Gieffers, Meinolf Thiemann
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Single-chain GITRL
scGITRL-RBD
GITR
Agonist
TNFSF
CD357
Online Access:http://link.springer.com/article/10.1186/s40425-019-0671-4

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http://link.springer.com/article/10.1186/s40425-019-0671-4

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