Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps

Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps

Triosephosphate isomerase (TIM) is a key enzyme in glycolysis that catalyses the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This simple reaction involves the shuttling of protons mediated by protolysable side chains. The catalytic power of TIM is thought to stem fr...

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Bibliographic Details
Main Authors: Vinardas Kelpšas, Octav Caldararu, Matthew P. Blakeley, Nicolas Coquelle, Rikkert K. Wierenga, Ulf Ryde, Claes von Wachenfeldt, Esko Oksanen
Format: Article
Language:English
Published: International Union of Crystallography 2021-07-01
Series:IUCrJ
Subjects:
triosephosphate isomerase
neutron diffraction
isomerization
quantum refinement
qm/mm
neutron crystallography
refinement
enzyme mechanisms
structural biology
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252521004619

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http://scripts.iucr.org/cgi-bin/paper?S2052252521004619

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