Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling

Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling

Abstract Background Gemcitabine (GEM) resistance remains a significant clinical challenge in pancreatic cancer treatment. Here, we investigated the therapeutic utility of everolimus (Evr), an inhibitor of mammalian target of rapamycin (mTOR), in targeting the Warburg effect to overcome GEM resistanc...

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Bibliographic Details
Main Authors: Jing Cui, Yao Guo, Heshui Wu, Jiongxin Xiong, Tao Peng
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Medicine
Subjects:
Pancreatic cancer
Gemcitabine
Everolimus
Drug resistance
Metabolism
Online Access:https://doi.org/10.1186/s10020-021-00300-8

Internet

https://doi.org/10.1186/s10020-021-00300-8

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