Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease

Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease

Lysosomal Storage Diseases (LSD) are genetic diseases causing systemic and nervous system dysfunction. The glia-derived lipid binding protein Apolipoprotein D (ApoD) is required for lysosomal functional integrity in glial and neuronal cells, ensuring cell survival upon oxidative stress or injury. He...

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Bibliographic Details
Main Authors: Raquel Pascua-Maestro, Miriam Corraliza-Gomez, Cristian Fadrique-Rojo, Maria D. Ledesma, Edward H. Schuchman, Diego Sanchez, Maria D. Ganfornina
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Neurobiology of Disease
Subjects:
Lysosomal storage disorder
Neuroprotection
Lysosomal pH
Lysosome permeability
Lipocalin
Lipid binding protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303211

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http://www.sciencedirect.com/science/article/pii/S0969996120303211

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