Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease

Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease

Huntington's disease (HD) is a devastating neurodegenerative disease characterized by the selective loss of neurons in the striatum and cerebral cortex. This study tested the hypothesis that an adenoassociated viral (AAV2) vector encoding for the trophic factor neurturin (NTN) could provide neu...

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Bibliographic Details
Main Authors: Shilpa Ramaswamy, Jodi L. McBride, Christopher D. Herzog, Eugene Brandon, Mehdi Gasmi, Raymond T. Bartus, Jeffrey H. Kordower
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Neurobiology of Disease
Subjects:
Huntington’s disease
Neurturin
Gene therapy
3-Nitropropionic acid
Adenoassociated viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000216

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http://www.sciencedirect.com/science/article/pii/S0969996107000216

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