Complex III Inhibition-Induced Pulmonary Hypertension Affects the Mitochondrial Proteomic Landscape

Complex III Inhibition-Induced Pulmonary Hypertension Affects the Mitochondrial Proteomic Landscape

The mitochondria play a vital role in controlling cell metabolism and regulating crucial cellular outcomes. We previously demonstrated that chronic inhibition of the mitochondrial complex III in rats by Antimycin A (AA) induced sustained pulmonary vasoconstriction. On the metabolic level, AA-induced...

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Bibliographic Details
Main Authors: Joel James, Mathews Valuparampil Varghese, Mikhail Vasilyev, Paul R. Langlais, Stevan P. Tofovic, Olga Rafikova, Ruslan Rafikov
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary arterial hypertension
mitochondria
complex III
metabolic dysfunction
fatty acid metabolism
Online Access:https://www.mdpi.com/1422-0067/21/16/5683

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https://www.mdpi.com/1422-0067/21/16/5683

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