The Acute Hepatic NF-κB-Mediated Proinflammatory Response to Endotoxemia Is Attenuated in Intrauterine Growth-Restricted Newborn Mice

The Acute Hepatic NF-κB-Mediated Proinflammatory Response to Endotoxemia Is Attenuated in Intrauterine Growth-Restricted Newborn Mice

Intrauterine growth restriction (IUGR) is a relevant predictor for higher rates of neonatal sepsis worldwide and is associated with an impaired neonatal immunity and lower immune cell counts. During the perinatal period, the liver is a key immunological organ responsible for the nuclear factor kappa...

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Bibliographic Details
Main Authors: Miguel A. Zarate, Robyn K. De Dios, Durganili Balasubramaniyan, Lijun Zheng, Laura G. Sherlock, Paul J. Rozance, Clyde J. Wright
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
liver
innate immunity
LPS
NF-κB
cytokines
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.706774/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.706774/full

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