Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenitor cells (NPCs) derived from FAD mutant PSEN1 s...

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Bibliographic Details
Main Authors: Andrew A Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W Steele, David J Kahler, Alex Dranovsky, Ottavio Arancio, John F Crary, Sam Gandy, Scott A Noggle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3885572?pdf=render

Internet

http://europepmc.org/articles/PMC3885572?pdf=render

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