In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Abstract Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT...

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Bibliographic Details
Main Authors: Ismail Adeniran, Dominic G. Whittaker, Aziza El Harchi, Jules C. Hancox, Henggui Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08367-2