Are the Effects of Oral and Vaginal Contraceptives on Bone Formation in Young Women Mediated via the Growth Hormone-IGF-I Axis?

Are the Effects of Oral and Vaginal Contraceptives on Bone Formation in Young Women Mediated via the Growth Hormone-IGF-I Axis?

Purpose: Combined hormonal contraceptive therapy has been associated with negative bone mineral density outcomes that may be route-dependent [i.e., combined oral contraception (COC) vs. contraceptive vaginal ring (CVR)] and involve the hepatic growth hormone (GH)/insulin-like growth factor-I (IGF-I)...

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Bibliographic Details
Main Authors: Heather C. M. Allaway, Madhusmita Misra, Emily A. Southmayd, Michael S. Stone, Connie M. Weaver, Dylan L. Petkus, Mary Jane De Souza
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Endocrinology
Subjects:
oral contraception
contraceptive vaginal ring
insulin-like growth factor-I
procollagen type I N-terminal propeptide
IGF-I generation test
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00334/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00334/full

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