Multifaceted Analyses of Epidermal Serine Protease Activity in Patients with Atopic Dermatitis

Multifaceted Analyses of Epidermal Serine Protease Activity in Patients with Atopic Dermatitis

The serine proteases kallikrein-related peptidase (KLK) 5 and KLK7 cleave cell adhesion molecules in the epidermis. Aberrant epidermal serine protease activity is thought to play an important role in the pathogenesis of atopic dermatitis (AD). We collected the stratum corneum (SC) from hea...

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Bibliographic Details
Main Authors: Hayato Nomura, Mutsumi Suganuma, Takuya Takeichi, Michihiro Kono, Yuki Isokane, Ko Sunagawa, Mina Kobashi, Satoru Sugihara, Ai Kajita, Tomoko Miyake, Yoji Hirai, Osamu Yamasaki, Masashi Akiyama, Shin Morizane
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
atopic dermatitis
serine proteases
kallikrein-related peptidases
epidermal barrier dysfunction
lympho-epithelial kazal-type-related inhibitor (lekti)
<i>spink5</i>
filaggrin
Online Access:https://www.mdpi.com/1422-0067/21/3/913

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https://www.mdpi.com/1422-0067/21/3/913

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