β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.

β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.

The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intracellular signaling cascade activated by Wnt. It also...

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Bibliographic Details
Main Authors: Noriko Okumura, Hidenori Akutsu, Tohru Sugawara, Takumi Miura, Youki Takezawa, Akihiro Hosoda, Keiichi Yoshida, Justin K Ichida, Mitsutoshi Yamada, Toshio Hamatani, Naoaki Kuji, Kenji Miyado, Yasunori Yoshimura, Akihiro Umezawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3653942?pdf=render

Internet

http://europepmc.org/articles/PMC3653942?pdf=render

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