Autologous Dendritic Cells in Combination With Chemotherapy Restore Responsiveness of T Cells in Breast Cancer Patients: A Single-Arm Phase I/II Trial

Autologous Dendritic Cells in Combination With Chemotherapy Restore Responsiveness of T Cells in Breast Cancer Patients: A Single-Arm Phase I/II Trial

IntroductionAnimal studies and preclinical studies in cancer patients suggest that the induction of immunogenic cell death (ICD) by neoadjuvant chemotherapy with doxorubicin and cyclophosphamide (NAC-AC) recovers the functional performance of the immune system. This could favor immunotherapy schemes...

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Bibliographic Details
Main Authors: David A. Bernal-Estévez, Mauren A. Ortíz Barbosa, Paola Ortíz-Montero, Claudia Cifuentes, Ramiro Sánchez, Carlos A. Parra-López
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
breast cancer
immunotherapy
dendritic cells
neoadjuvant chemotherapy
clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669965/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.669965/full

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