Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids

Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids

In protein engineering and synthetic biology, <i>Methanosarcina mazei</i> pyrrolysyl-tRNA synthetase (<i>Mm</i>PylRS), with its cognate tRNA<sup>Pyl</sup>, is one of the most popular tools for site-specific incorporation of non-canonical amino acids (ncAAs). Numer...

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Bibliographic Details
Main Authors: Hsueh-Wei Tseng, Tobias Baumann, Huan Sun, Yane-Shih Wang, Zoya Ignatova, Nediljko Budisa
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
aromatic amino acid analogs
site-specific incorporation
genetic code expansion
<i>Methanosarcina mazei </i>pyrrolysyl-tRNA synthetase (<i>Mm</i>PylRS)
non-canonical amino acids (ncAAs)
orthogonal pairs
Online Access:https://www.mdpi.com/1420-3049/25/19/4418

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https://www.mdpi.com/1420-3049/25/19/4418

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