Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction

Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction

Clinical use of the chemotherapeutic doxorubicin (DOX) promotes skeletal muscle atrophy and weakness, adversely affecting patient mobility and strength. Although the mechanisms responsible for DOX-induced skeletal muscle dysfunction remain unclear, studies implicate the significant production of rea...

Full description

Bibliographic Details
Main Authors: Vivian Doerr, Ryan N. Montalvo, Oh Sung Kwon, Erin E. Talbert, Brian A. Hain, Fraser E. Houston, Ashley J. Smuder
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Antioxidants
Subjects:
adriamycin
antioxidant
mitochondria
peroxisome proliferator-activated receptor gamma co-activator 1-alpha
chemotherapy
Online Access:https://www.mdpi.com/2076-3921/9/3/263

Internet

https://www.mdpi.com/2076-3921/9/3/263

Similar Items