Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion

Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion

<p>Abstract</p> <p>Background</p> <p>We recently provided evidence that HIV-1 enters HeLa-derived TZM-bl and lymphoid CEMss cells by fusing with endosomes, whereas its fusion with the plasma membrane does not proceed beyond the lipid mixing step. The mechanism of restri...

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Bibliographic Details
Main Authors: de la Vega Michelle, Marin Mariana, Kondo Naoyuki, Miyauchi Kosuke, Kim Yuri, Epand Raquel F, Epand Richard M, Melikyan Gregory B
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Retrovirology
Subjects:
HIV fusion kinetics
hemifusion
fusion pore
dynasore
temperature-arrested intermediate
fusion inhibitors
single particle tracking
beta-lactamase
intrinsic membrane curvature
Online Access:http://www.retrovirology.com/content/8/1/99

Internet

http://www.retrovirology.com/content/8/1/99

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