A Synthetic Hydrogel, VitroGel® ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells

A Synthetic Hydrogel, VitroGel® ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells

Immunosurveillance of the gastrointestinal epithelium by mononuclear phagocytes (MNPs) is essential for maintaining gut health. However, studying the complex interplay between the human gastrointestinal epithelium and MNPs such as dendritic cells (DCs) is difficult, since traditional cell culture sy...

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Bibliographic Details
Main Authors: Michelle D. Cherne, Barkan Sidar, T. Andrew Sebrell, Humberto S. Sanchez, Kody Heaton, Francis J. Kassama, Mandi M. Roe, Andrew B. Gentry, Connie B. Chang, Seth T. Walk, Mark Jutila, James N. Wilking, Diane Bimczok
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
microphysiological system
gastric organoid
mononuclear phagocyte
dendritic cell
chemotaxis
matrigel
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.707891/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.707891/full

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