Adaptive evolution of the vertebrate skeletal muscle sodium channel

Adaptive evolution of the vertebrate skeletal muscle sodium channel

Tetrodotoxin (TTX) is a highly potent neurotoxin that blocks the action potential by selectively binding to voltage-gated sodium channels (Na v). The skeletal muscle Na v (Na v1.4) channels in most pufferfish species and certain North American garter snakes are resistant to TTX, whereas in most mamm...

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Bibliographic Details
Main Authors: Jian Lu, Jianzhou Zheng, Qinggang Xu, Keping Chen, Chiyu Zhang
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2011-01-01
Series:Genetics and Molecular Biology
Subjects:
skeletal muscle voltage-gated Na (Na v1.4) channel
tetrodotoxin (TTX)
positive selection
pufferfish
garter snake
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200026

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200026

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