Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ

Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ

A series of novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives have been synthesized and evaluated as glucokinase (GK) activators. Ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl-amino)thiazole-5-carboxylate was found to be a potent dual-acting hypoglycemic agent activating bot...

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Bibliographic Details
Main Authors: Hui-peng Song, Kang Tian, Lei Lei, Zhu-fang Shen, Shou-xin Liu, Li-juan Zhang, Hong-rui Song, Xiao-feng Jin, Zhi-qiang Feng
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Diabetes
Multi-target therapy
Glucokinase activators
PPARγ
N-(pyrimidin-4-yl)thiazol-2-amine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511000670

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http://www.sciencedirect.com/science/article/pii/S2211383511000670

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