Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

Glioblastoma (GBM) is the most frequent malignant glioma. Treatment of GBM patients is multimodal with maximum surgical resection, followed by concurrent radiation and chemotherapy with the alkylating drug temozolomide (TMZ). The present study aims to identify genes implicated in the acquired resis...

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Bibliographic Details
Main Authors: Benjamin Le Calvé, Michal Rynkowski, Marie Le Mercier, Céline Bruyère, Caroline Lonez, Thierry Gras, Benjamin Haibe-Kains, Gianluca Bontempi, Christine Decaestecker, Jean-Marie Ruysschaert, Robert Kiss, Florence Lefranc
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800740

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http://www.sciencedirect.com/science/article/pii/S1476558610800740

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